The five bedroom home at 75 Campbell Street was once a hive of activity for Queanbeyan's mothers-to-be, where Nurse Mary Johnston delivered hundreds of babies from 1910 to 1944.

The home was built for Mrs Johnston and her family in 1908, two years before she registered the building as a lying-in birthing hospital and several decades before Canberra and Queanbeyan hospitals opened maternity wards.

The historic home is now on the market, and owner Sue Borgo said the nine years that she and her family have lived there have been punctuated by nostalgic visitors.

“Over the years, we've had people come knock on the door and say they were in this home,” she said.

“People have a soft spot for the house. Everyone here seems to know it.”

Ms Borgo and her family are the home's third owners after the Johnston family sold the property more than 30 years ago.

After the last baby was born in November 1944, Mrs Johnston converted the home into a boarding house which she managed until her death in 1948. Three generations of the Johnston family continued living there until 1980.

Ms Borgo, also a nurse, said the home doesn't resemble what it used to – it now features solar panels and irrigation for the garden – but “it's still kept fairly traditional”.

The Borgo family also funded a documentary exploring the work of Mrs Johnston and the role of the “Yvonne” Private Hospital, featuring interviews with two “Yvonne” babies.

“History gets forgotten far too often,” Mrs Borgo said.

She also received a box of historical pieces from the previous owner, including a list of necessary items such as Dettol, castor oil and “toilet soap”, as well as an ad posted in the Queanbeyan Age dated April 22, 1930.

“Yvonne” is on the market for offers above $750,000 and is open for inspection from 11am on Saturday.