A motorist has died following a single car crash near Goulburn on Friday morning.

NSW police said he 49-year-old man was driving his Toyota Kluger north along the Hume Highway at Yarra about 5.15am on Friday.

Approximately three kilometres north of South Head Road, the 4WD left the road and crashed into a tree on the centre nature strip.

The man from Eastwood died at the scene.

Police from Goulburn Local Area Command examined the scene and will include all information in a report for the coroner.