Fremantle has lost ruck star Aaron Sandilands, but Carlton has also been hit hard by injury for Friday night's AFL clash in Perth.
Sandilands is out with a knee injury, but the Dockers have regained another key player, Nathan Fyfe, from a shoulder injury.
The Blues have lost Andrew Carrazzo (shoulder), Chris Yarran (toe) and Jeremy Laidler (knee), while dropping Brock McLean and Paul Bower from the side that lost to Essendon last round.
But last year's leading goalkicker, Andrew Walker, returns from injury for his first game of the season.
Melbourne welcomes back co-captain Jack Grimes and forward-midfielder Colin Sylvia for their first games of the season, against St Kilda at the MCG on Saturday night.
But big forward Mitch Clark (neck) will miss the match, after falling on his head in a marking contest last weekend.
The Saints lost Justin Koschitzke (suspension), but regained Jason Gram.
North Melbourne dropped ruckman Todd Goldstein for Saturday night's Etihad Stadium meeting with Gold Coast.
The Suns lost superstar Gary Ablett (knee) and Jarrod Harbrow (elbow), but Michael Rischitelli was named despite an ankle concern.
Hawthorn captain Luke Hodge was named on an expanded interchange bench for what might be his first game of the season, against the Sydney Swans in Launceston on Sunday.
The Swans regain co-captain Adam Goodes from suspension to play a club record 304th AFL game, while Lewis Roberts-Thomson could return, after being named on their expanded bench.
Adelaide lost midfielder Bernie Vince (hand) for Sunday's showdown against Port Adelaide, who will be without forward Robbie Gray (knee) for the rest of the season.
Geelong veteran defender Matthew Scarlett returns from suspension to take on Brisbane at the Gabba on Saturday night.
Experienced Western Bulldogs backman Brian Lake also returns from suspension, as the Dogs seek their second straight win, against Greater Western Sydney in Canberra on Saturday.
But the Bulldogs have lost forward Daniel Giansiracusa to a hip injury.
The Giants will be without experienced pair Dean Brogan (back) and Rhys Palmer (groin).
Former Bulldog Sam Reid will make his Giants debut against his ex-teammates, while No.13 draft pick Taylor Adams, who is facing an assault charge, was named for his AFL debut.
Richmond has dropped Addam Maric for Sunday's Etihad Stadium encounter with unbeaten West Coast, who have not made any cuts from their squad.