Brumbies coach Jake White has thrust a fellow South African into the Brumbies pack to confront the Bulls in Saturday night's Super Rugby clash, but the Canberra-based side will again miss the services of red-hot fullback Jesse Mogg.

South African-born lock Etienne Oosthuizen is set to debut for the competition leading Brumbies at Canberra Stadium with White ringing in four run-on changes for their third straight match against South African heavyweights.

There's only one change in the backline, with halfback Nic White recovering from a shoulder injury to reclaim the No.9 jersey from Ian Prior.

However in a big blow to the Brumbies, the Australian conference's standout fullback Mogg has failed to recover from his shoulder problem.

"He'll be fine maybe next week I just don't want to risk him," White said.

Oosthuizen - who played three Super Rugby games in 2012 for the Lions - comes in at second row alongside a fresh Scott Fardy, with Sam Carter being rested from the game with a sore shoulder and Peter Kimlin moving back to blindside flanker.

With the Lions relegated at the expense of the Southern Kings after the 2012 season, White moved quick to nab the services of the 120kg 20-year-old Oosthuizen who measures just a shade under two metres tall.

"It's the right time, he knows a lot of these boys (Bulls players) as he's played against a lot of them when he was in the Currie Cup," White said.

Meanwhile, Fotu Auelua drops to the bench, captain Ben Mowen shuffles across to No.8 and prop Ben Alexander makes a straight swap with Scott Sio after having a rest on the bench in last week's 35-22 loss against the Stormers in Cape Town.

"It's rotating, but it's also making sure we keep the squad fit and available and also creating opportunities for other boys," White said.

The Bulls have made just as many changes to their side, with injuries, rather than rotation, being the main factor.

However the Brumbies will have to play the part of disciplined matadors against their wounded opponents, with sharpshooting flyhalf Morne Steyn working his way back into the run on side.

The Bulls are also desperate to cap off their four week tour of New Zealand and Australia with a victory to give themselves a pass mark of two wins from four games after narrowly going down to the Reds in Brisbane last week.

Brumbies: Robbie Coleman, Henry Speight, Tevita Kuridrani, Christian Lealiifano, Joe Tomane, Matt Toomua, Nic White, Ben Mowen (c), George Smith, Peter Kimlin, Etienne Oosthuizen, Scott Fardy, Dan Palmer, Stephen Moore, Ben Alexander. Res: Siliva Siliva, Scott Sio, Fotu Auelua, Colby Faingaa, Ian Prior, Andrew Smith, Clyde Rathbone.