He is most famous as troubled physician Gregory House, now Hugh Laurie is preparing to play yet another difficult doctor.
The British comic turned dramatic actor will star as the lead character in a new made-for-streaming US drama Chance, based on the 2014 psychological suspense novel by Kem Nunn, according to Deadline.
Set in San Francisco, the story centres on Eldon Chance, a lonely forensic neuropsychologist who has an affair with one of his patients and is dragged into the city's criminal underbelly.
His love interest is the abused wife of a dangerous homicide detective with whom she has just separated, and has a multiple personality disorder.
The Fox production will air on US streaming site Hulu in late 2016 and has been given a generous two-season, 20-episode order.
Laurie, a two-time Golden Globe winner, was reportedly the first choice for the role, and was approached by Fox nearly 18 months ago. He will also serve as an executive producer on the series.
After a successful career in iconic British comedies such as Blackadder, Laurie made his foray into drama with long-running Fox series House in 2004.
Running until 2012, Laurie played a drug-dependent, highly-dystfunctional medical genius at a New Jersey hospital, which earned the actor two Golden Globe Awards and six Emmy nominations.
He has reportedly been heavily pursued to headline new series since the conclusion of House, but declined every offer.
Chance comes as a major boon for Hulu, with Laurie a highly-recognisable star. According to Deadline, the show has the potential to raise Hulu's profile in the same way House of Cards did for Netflix.
Kevin Spacey's political drama found a home at Netflix in 2011 after negotiations with networks like HBO fell through, and has become of the most talked-about shows in the United States.