On September 19 the world's most isolated city will be awash with fluorescent green, neon yellow and hot pink, with a suitably loud score thanks to local indie-pop rockers San Cisco for the kick off of the 2012 Perth Fashion Festival.

"This year we are breaking with tradition, taking on new formats and events to spice it up," Festival director Mariella Harvey-Hanrahan said at Tuesday's program launch.

More than 150 designers will take part in the 14^th annual event including One Fell Swoop, Morrison and Ae’lkemi.

Special guests and ambassadors will include Singaporean socialite and blogger Marie Choo, celebrity and L'Oreal Professional hairstylist Brad Ngata and Face of the Festival, Dior darling Nicole Pollard.

The highlights, which were unveiled today to fashion insiders and VIPS over a breakfast of champagne and fruit kebabs at the State Theatre Centre, will include a special trunk show by Flannel.

At "An Evening with Flannel" guests will be a served a three-course meal and French Champagne and take in the 1920s inspired showcase of the spring/summer collection Neronis styled by ex-Vogue fashion editor Meg Gray.

Boutique owner and stylist Zara Bryson will lead the charge of "Fashionably Loud" at Brookfield Place which will fuse models, music by rock stars of the future San Cisco and mode by Ellery, Belle Bijoux and Kitty Grace.

For the first time there will be shows which cater for those who are vision impaired. Some shows will also feature seeing eyes dogs on the catwalk.

Deputy Lord Mayor Janet Davidson said that past Perth Fashion Festival events had a $6 million impact within the City of Perth's retail precinct.

Perth Fashion Festival runs from September 19 through to September 25.