Two of the four Italian girls involved in a custody battle had to be moved to another flight.

Two of the four Italian girls involved in a custody battle had to be moved to another flight. Photo: Cade Mooney

ALL FOUR SISTERS involved in an international custody dispute have now departed for Italy.

The girls' great aunt says the two eldest girls flew out of Brisbane just after 8pm last night, to join their younger siblings, who had left on a flight the night before.

The elder two were also due to be on that flight but were taken off after throwing a tantrum.

They were traumatising other passengers by screaming and kicking and four federal police escorts were unable to restrain them.

The four sisters, aged nine to 15, were forcefully removed from their Sunshine Coast home earlier after a Brisbane judge dismissed the mother's last-ditch application to keep them in Australia.

The two girls had stayed at the Novotel hotel at Brisbane Airport overnight on Wednesday.

Their mother has no immediate plans to fly to Italy, despite her daughters being sent there on a judge's orders, their great-grandmother said yesterday.

The great-grandmother of the four girls vowed ''this is not over'' but said their mother was too scared to fly to Italy and did not have the money to get there.

The sisters were being sent back to Italy for their parents' custody case to be heard under Italian jurisdiction, on the orders of a Brisbane judge.

The girls' great-grandmother said the family was devastated but the girls' mother would ''dare not'' return to Italy.

''I'm pretty darn sure she will not go back because she knows what waits for her,'' she said.

The girls have not been forced to travel to Italy to live with their father, but rather to have their custody case heard under Italian jurisdiction.

With AAP