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Scientists hopeful of diabetes cure

14 Nov, 2008 06:33 AM
People living with diabetes have reason to hope as they mark World Diabetes Day today.

More people throughout the developed world are being diagnosed with the disease, but researchers are racing to find a cure and Australian researchers are at the leading edge.

Many researchers are positive they will develop an accessible cure in their lifetimes.

Juvenile Diabetes Research Foundation chief executive Mike Wilson said it was important to recognise how far researchers had come in the past few decades.

A diagnosis of Type 1 diabetes 35 years ago would have meant having to inject with a glass syringe sharpened on a stone and having to boil urine on a stove to measure blood sugar levels.

''The tools and techniques available for day-to-day management, which is still a challenge, are vastly improved,'' Mr Wilson said.

''Many of the researchers of whom we speak are very confident that a cure will be found in their lifetime and to me, that's very positive because some of them are well-established and have a lot of grey hair.''

There are two large research endeavours in Australia in the area of Type 1 diabetes: one is developing a cure for the disease and the other creating a vaccine.

The first is a national pilot transplant program, which runs out of Westmead Hospital in Sydney and St Vincent's Hospital in Melbourne. It involves separating insulin producing cells from a donated pancreas.

Rather than transplanting the whole organ, just the insulin producing cells can be transplanted into someone with Type 1 diabetes.

Professor of endocrinology at the Garvan Institute Don Chisholm said each centre had achieved successful transplants with a handful of patients.

''But it's a very difficult and expensive procedure and its early days yet in Australia,'' Professor Chisholm said.

''At the moment, it still requires substantial immunosuppressive drugs, as would be needed if you transplanted any other organ.''

Another project involves developing a nasal spray Type 1 diabetes vaccine.

A trial for the vaccine, called the INIT II Type 1 diabetes prevention trial, is taking place across Australia and researchers are looking for test subjects. Researchers plan to involve hundreds of people who are relatives of people with diabetes.

The trial will involve using insulin sprayed into the nose, which could divert the immune system away from attacking the insulin producing cells in someone with Type 1 diabetes.

''If the trial is successful, then it would be an enormous step down the track [to a prevention],'' Professor Chisholm said.

In the past 10 years, Type 1 diabetes has doubled in children under the age of five. Across all ages, Type 1 diabetes is increasing at a rate of about 3 per cent each year.

Mr Wilson said the cost of delay in finding a cure was measured in the people impacted by the disease.

''It's measured not just in years but in the five people that are diagnosed every day and the people who suffer heart attacks or lose limbs or go blind every year as a result of complications,'' he said.

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As a mum of a child that has Type 1 diabetes not a day goes by when I don't hope and pray for a cure...
Posted by Carer, 14/11/2008 8:50:33 AM
"A diagnosis of Type 1 diabetes 35 years ago would have meant having to inject with a glass syringe sharpened on a stone and having to boil urine on a stove to measure blood sugar levels." I've been diabetic for 34 years and I don't recall this procedure. Maybe someone needs to do more research!
Posted by Darkfox, 14/11/2008 11:10:29 AM
What a load of rubbish that a Type 1 diabetic had to sharpen the needle on a stone and boil urine to measure blood sugar levels. I have been a Type 1 diabetic for 41 years, and I used sterile needles and urine test strip which were available when I was diagnosed. However, I do agree that tools and techniques for day-to-day management have vastly improved. I hope a cure becomes available soon.
Posted by Charles, 14/11/2008 12:43:03 PM
Personally, I don't like the idea of taking anti-rejection drugs for the rest of my life, diabetes has fewer side-effects if managed properly. The 'cure' I'm keeping my eye on is a procedure by Living Cell Technologies which takes porcine islet cells and encapsulates them in some special gell, so that they can produce insulin and protect the islet cells from your immune system, hence, no immunosuppresants!
Posted by Shaun, 14/11/2008 7:47:23 PM
i am 15 year old girl who has lived with diabetese since i was seven, but have alswas been around diabetics. the majority of my family are diabetics, and we all hope and pray that a cure will be found. i have heard of many possibilities of a cure but have many questions to ask, that to me seem a logical way to become 'un-diabetic - why dont we just have a pancraese translplant, why do we not have extra doses of hormones every moth, take tablets that have the same effect as insulin. i know that times have moved on, and i do understand that trails are expensive, but as a teenage girl, ifeel left out and want a cure to come quickly. it may seem selfish as some people may have had daibetese for a lot longer than me, but i feel that this disease can cause major self esteem problems and reduce the likliness of jobs.
Posted by Diabetic Girl, 14/11/2008 9:39:57 PM
I'm sceptical!! as much as I WISH development of a cure would go on the fastrack... even if one DOes become reality - are all those companies out there who produce the blood testing kits, the injectors, manufacturers of insulin, etc etc are they just going to roll over and wish us well - Just How do you get a Cure past these guys who are making millions by "Treating" the condition. Would they truly welcome a Cure, or atempt to Prevent it's release?!!!?
Posted by sceptical, 14/11/2008 11:30:02 PM
With respect to Charles & Dark Fox, I am very disappointed at their attitude. The state of diabetes care and the technology relating to diabetes has been very slow to advance. Fast acting insulin analogs are only a very recent development and are not still universally used or available. Children in India and Africa die every day because of lack of insulin...and dying in a diabetic coma or through multiple organ failure because of diabetes is very real and not a "load of rubbish". Today is "World Diabetes Day' and I have been looking at the news here in the USA and you would never know. I was part a lobbying group to get Google to acknowledge World Diabetes Day with a Google doodle...they did not get the 20,000 petitions that they insisted they needed to do a doodle. I would encourage everyone to make their best effort to highlight the necessity to support research for a cure and support for those afflicted. And less cynicism would help. Having survived diabetes for 40+years is an achievement, given that when one would have been diagnosed with diabetes in 1968 your life expectancy would be at a maximum 35 more years..both Darkfox and Charles have beaten the odds. However it does not qualify you to make theses comments, autoclaves and glass syringes were all that were available in the 1960's. It was not until 1961 that BD launched the first disposable syringe and it took a couple of years before they became universally available, similarly with glucose monitoring it was only in the very late sixties that units became available and they cost $000's in today's dollars. We need to keep advancing towards a cure and not diminish the struggle.
Posted by Michael, 15/11/2008 2:15:16 PM
this is wonderful.. my sister diabetes and i am so happy she wont have to go through the struggles anymore.
Posted by kay*, 19/11/2008 12:11:38 PM
i hate diabetes i really need a cure
Posted by spydued, 19/11/2008 2:19:52 PM

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