A 74-year-old man has died in hospital after a car accident on the Hume Highway at Gunning.

Police said a Toyota Hilux and a Holden Commodore, travelling in the same direction, collided about 2.50pm on Tuesday.

The Hilux left the road and overturned before coming to rest on an embankment.

Emergency services freed the man from the vehicle and he was airlifted to the Canberra Hospital suffering from abdominal injuries.

Police said the man died later on Tuesday. A report will be prepared for the coroner.