The scene of the fatal crash involving a male pedestrian and a bus on George St this afternoon.

The scene of the fatal crash involving a male pedestrian and a bus on George St this afternoon. Photo: Rachel Browne

Another pedestrian has died after he was struck by a bus in Sydney's CBD, the second fatal crash involving a bus in the city in as many days.

The man, described as aged in his 30s, was hit on George Street, near Liverpool Street, about 2.30pm. He died at the scene.

All northbound lanes and two of three southbound lanes on George Street were closed until 4.30pm. 

A tow truck removes the bus involved in the fatal crash.

A tow truck removes the bus involved in the fatal crash. Photo: Rachel Browne

On Sunday, a pedestrian was hit and killed by a bus in Haymarket, while on Thursday, a cyclist was killed in a collision with a bus in Neutral Bay.

Police said they believed the latest victim was struck by the northbound bus after he stepped onto George Street, near the Three Wise Monkeys pub.

The bus driver, who was uninjured, has been taken to hospital for mandatory blood and urine testing.

Rick Theobold, who was near the scene of the crash, said the man appeared to have been struck in the head by the side mirror of the bus.

He said onlookers rushed to the man's aid but he was bleeding heavily from a head injury.

Another witness, Steve, said the man stepped out in front of the public bus.

"He just stepped out without looking. I think he might have been trying to beat the lights," he said.

"It goes to show, always wait for the green man. One minute you're here. The next you are not."

Ambulance staff had performed CPR on the man for some time but there was nothing they could do to help him. He appeared to be aged in his 30s.

A worker at the hungry jacks restaurant opposite the scene said there were often near misses at the intersection.

"People are always in a rush," said Brett, who did not give his surname.

"They try to beat the lights and they don't look for traffic."

Monday's fatality comes just over 24 hours after a man, believed to have been a sketch artist, died after being struck by a coach that lurched into a popular Chinese restaurant in Haymarket on Sunday.

Witnesses say the man appeared to be killed instantly when the coach left Hay Street in Haymarket, mounted the footpath, and crashed into the Emperor's Garden restaurant on Dixon Street about midday on Sunday.

Peter Henphill, who was standing near the man when he was struck by the bus, said he appeared to be a sketch artist and of Asian origin.

"All his sketches were under the bus with him," Mr Henphill said. "They were portraits of people, headshots. They were all scattered everywhere."

Buses are one of the biggest killers of pedestrians in Sydney's central business district. Figures obtained using freedom of information laws show they are responsible for almost half of all pedestrian deaths in the city, despite making up 10 per cent of traffic volumes.

Prior to Sunday's incident, there had been 11 fatal collisions between vehicles and pedestrians in Sydney's CBD. Five of them had involved buses.

More to come