A car accident near Goulburn has left one woman with minor injuries and caused major traffic disruptions on the Federal Highway, with one south-band lane closed for about an hour.

The incident was reported about 9.50am Friday. NSW Ambulance said a car hit the guard rail and flipped.

It occurred on the Federal Highway between Goulburn and Collector, near the intersection with the Hume Highway.

The 20-year-old female driver was treated for minor injuries at the scene before being taken to Goulburn Hospital. She was in a stable condition at 10.30am.

The accident caused significant traffic disruptions. One south-bound was closed, but it was reopened about 11.10am.

A number of emergency services attended the scene including Goulburn police, NSW Ambulance and Fire & Rescue.