Josh Beaumont, son of former captain Bill, is one of seven uncapped players included in former Wallabies coach Eddie Jones's first England squad, while several regulars of the previous regime have been culled.
Jones named a 33-man Elite Player Squad on Wednesday, effectively his squad for the Six Nations championship starting next month with England visiting Scotland in their first game on February 6.
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"The long-term strategy for England is to develop a side who can be the most dominant team in world rugby, so we have chosen a lot of new players on the growth we see in them," said Jones, who will name his captain at a later date.
"We see these players growing into England players of the future and developing into a side who can be the best in the world. Our aim is to develop a squad where there is depth and competition in every position."
Beaumont is a powerful No.8 in the mould of his father, one of England's most iconic players who led them to the grand slam in 1980 and captained the British and Irish Lions the same year.
Flanker Jack Clifford and England's World Cup captain Chris Robshaw have both been included.
Elliot Daly is included and has a chance to press for a team slot in the absence of injured Henry Slade, while Sam Hill, Paul Hill, Ollie Devoto and Maro Itoje are also included hoping for a first cap.
Centre Manu Tuilagi, who last played for England in June 2015, was not included in the squad but will be considered after the early games of the Six Nations.
Several players who were regulars under Stuart Lancaster have been left out, including centre Luther Burrell who was a regular in last year's Six Nations.
Fellow centre Brad Barritt, flanker Tom Wood, lock Geoff Parling, hooker Tom Youngs and No.8 Ben Morgan also miss out.
There was also no place for Danny Cipriani, whose international career now looks to be over.
Matt Kvesic, seen by many as the answer to England's search for a ball-snaffling No.7, was included.
There was a recall for winger Chris Ashton, who played only two Tests since 2013, and Marland Yarde, with both men hoping to take advantage of the season-ending knee injury of Jonny May.
Josh Beaumont (Sale Sharks), Dan Cole (Leicester Tigers), Luke Cowan-Dickie (Exeter Chiefs), Jack Clifford (Harlequins), Jamie George (Saracens), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Maro Itoje (Saracens), George Kruis (Saracens), Matt Kvesic (Gloucester Rugby) *injury replacement for Dave Ewers (Exeter Chiefs), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Matt Mullan (Wasps), Chris Robshaw (Harlequins), Henry Thomas (Bath Rugby) *injury replacement for Kieran Brookes (Northampton Saints), Billy Vunipola (Saracens), Mako Vunipola (Saracens).
Chris Ashton (Saracens), Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Ollie Devoto (Bath Rugby) *injury replacement for Manu Tuilagi (Leicester Tigers), Owen Farrell (Saracens), George Ford (Bath Rugby), Alex Goode (Saracens), Sam Hill (Exeter Chiefs) *injury replacement for Henry Slade (Exeter Chiefs), Jonathan Joseph (Bath Rugby), Jack Nowell (Exeter Chiefs), Anthony Watson (Bath Rugby), Marland Yarde (Harlequins), Ben Youngs (Leicester Tigers).