Both teams have secured their spots in the top four, but Wests/UC batsman Blake MacDonald says striking a psychological blow over Weston Creek Molonglo could be vital if they meet in the ACT Premier Cricket grand final.
Creek have more to play for out of the two sides when they square off at Stirling Oval in the last round of the competition, starting on Saturday.
Wests/UC have locked up top spot on 44 points with Creek in second on 30.
Creek could drop back to third and give up home-ground advantage in the semi-finals if they lose, with North Canberra Gungahlin (24 points) and Eastlake (22) within striking distance.
Norths and Eastlake face each other in the final round, with the loser knowing Queanbeyan (14) can still overtake them for the last spot in the top four.
Wests/UC have been the dominant side in the two-day format this season, but are wary of a quality Creek side back at full strength.
"It would be good if we could get that leg up on Creek and try to get that mental edge on them," MacDonald said.
"It's going to be a well-fought contest, it always is between our two sides over the last year and a bit.
"There's a bit of a rivalry there, so there will be no love lost."
Creek boast an experienced batting line-up featuring Adelaide Strikers batsman Jono Dean and former Tasmania and WA batsman John Rogers.
They also have a quality bowling attack including Djali Bloomfield, leg-spinner Mac Wright and fast bowler Joe Slater.
MacDonald said his side's bowling had been fantastic in recent weeks and it was up to the team's batsmen to become more consistent.
Queanbeyan will fancy their chances of making a late dash at the top four when they take on bottom-placed Ginninderra at Kippax.
Eastlake host Norths at Kingston Oval, while Tuggeranong and ANU will be looking to finish disappointing seasons on a high when they meet at Chisholm.
Meanwhile, ACT Comets captain Aiden Blizzard has been forced to pull out of Monday's Futures League game against Queensland at Allan Border Field with a back injury.
Blizzard's place in the side will be taken by Australian under-19 spinner Ben Taylor.
Eastlake skipper Michael Spaseski will take over the captaincy of the Comets.
ACT PREMIER CRICKET
Saturday: Round 14: Weston Creek Molonglo v Wests/UC at Stirling Oval. Ginninderra v Queanbeyan at Kippax. Eastlake v North Canberra Gungahlin at Kingston Oval. Tuggeranong v ANU at Chisholm.