Melissa Breen in the heats of the Stawell Gift, alongside Glenn Ross and Stuart Aberdein.

Melissa Breen in the heats of the Stawell Gift, alongside Glenn Ross and Stuart Aberdein.

Australia's 100m women's record holder Melissa Breen has called for a change to the Stawell Gift handicap system after she bowed out of the opening round of the prestigious men's event.

The Canberra sprinter was attempting to become the first female to reach the semi-finals of the Stawell Gift, but finished fourth in her heat on Saturday in a time of 12.95 seconds.

Breen ran off a handicap of 10m for the 120m journey, which was the most allowed under recent changes.

Melissa Breen runs in the women's event.

Melissa Breen runs in the women's event.

She was only 0.14 seconds off progressing to the semi-finals, with Glen Ross winning the heat in a time of 12.81 seconds.

"Ten metres is not enough and it's not as if they are all on scratch, either. They're at seven or eight metres," Breen said.

"It's a hard task and I will attempt it again, but I wish they could give me a cheeky few metres.

"I held my own for a bit and they came over the top at the end."

Breen was also eliminated from the women's gift, finishing third in her heat in a time of 13.88 seconds.

There was better news for training partner Brendan Matthews, who won his heat to book a berth in Monday's semi-finals.

Matthews claimed victory in a time of 12.59 seconds despite nursing a hamstring injury.

Five-time Paralympic gold medallist Evan O'Hanlon missed a spot in the semis after finishing third in his heat, and defending Gift champion Andrew Robinson was eliminated in the opening round.

Isaac Dunmall was the quickest heat winner with 12.32, which resulted in his price being slashed to $2.50 before Monday's semi-finals and final.

The next fastest heat runners were Gus Carty-Cowling (12.34), John Adams and Luke Versace (both 12.35).

Novice sprinter Chris Innes-Wong justified the faith and finances of his father, winning his heat in 12.40 seconds after his odds were slashed from $101 to $3 after a big plunge by Vincent Wong.