Australia will play two uncapped fast bowlers for the first time in three years after Joel Paris and Scott Boland were told on Monday they will make their one-day international debuts against India.
Kane Richardson, the paceman squeezed out of Australia's 13-man squad, made his debut with Ben Cutting against Sri Lanka in January 2013, the last time two speedsters were presented with their coloured caps in the same game.
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Joe Burns and Lendl Simmons set up a comfortable total for Brisbane, but a series of fielding mishaps almost allow the Sixers to chase it down.
Meanwhile, Shaun Marsh has been dealt another selection blow, missing out on international honours again despite being in rich form.
Marsh was the unlucky man of Australian cricket when he was dropped for the Boxing Day Test in place of the returning Usman Khawaja after plundering 182 against the West Indies in Hobart. Since then he has made 218 runs in the Big Bash at an average of 72.67.
Marsh was also the second-highest run scorer in the Matador Cup with 390 runs at 65, while four of his Australian teammates averaged below 25 with the bat in the tournament.
Compared with the numbers of Aaron Finch (112 runs at 18.66), George Bailey (122 at 24.4), Glenn Maxwell (78 at 15.6) and Mitch Marsh (119 at 23.80) during last year's domestic one-day competition, Marsh has good reason to feel hard done by.
Australian skipper Steve Smith sympathised with Marsh, but pointed out the 32-year-old did not feature in Australia's last limited-overs match, against England in September.
"He's playing exceptionally well, so it's a tough call on him," Smith said. "He hasn't whinged once. He's taken it on the chin and he's been great around the group. Hopefully every time he can go back [to state cricket] he can continue to dominate and keeps scoring big runs and put his name up there."
Paris, a 23-year-old left-armer from Western Australia, will make his debut in front of his home crowd and is expected to take the new ball with Josh Hazlewood on a more bowler-friendly Perth pitch than the one served up for the Test against New Zealand earlier in the summer.
"Traditionally we like playing a left-armer here that can use the breeze and swing the ball, so hopefully he [Paris] will be able to do that for us tomorrow," Smith said. "The wicket looks like it will be a pretty good one. It looks a little soft under foot at the moment. Hopefully it's got a bit more pace and bounce than the Test."
Boland gets his opportunity after being called into the Melbourne and Sydney Test squads after impressive performances for Victoria during the past two years.
Smith said it was a "luxury" to have five quicks who could make it difficult for India's batsmen to score freely late in an innings.
"His [Boland's] death bowling has been very impressive," Smith said. "I think he hits a yorker as well as anyone at the moment and he's got a bit of pace to him, so hopefully he can hurry up the Indian batsmen a bit. All of our fast bowlers in the game can perform a role at the death."
Bailey, Maxwell and Mitchell Marsh will fill Australia's middle order as they look to stamp their authority on the five-game series starting at a place Smith described as a "fortress" for the hosts in recent years.
Smith admitted he had paid little attention to the tourists' two practice matches against a WA XI, but made it clear his side would not be underestimating them.
"India have performed extremely well in one-day cricket for the last couple of years and we're not going to be taking them lightly," Smith said. "We're going to have to be at our best if we're going to beat them."
There was concern for Smith when he was hit in the groin during training after edging a throwdown, but after five minutes on the ground in pain he shrugged off the knock and continued his net session.
Final 11: David Warner, Aaron Finch, Steve Smith (c), George Bailey, Glenn Maxwell, Mitchell Marsh, Matthew Wade, James Faulkner, Joel Paris, Scott Boland, Josh Hazlewood.