As vote counting continued following Saturday's election, Labor was on track to hold as many as 49 seats - up one on its previous numbers.

The Liberal National Party appeared to have lost a net two seats, taking its numbers to 36 in the 93-seat chamber.

Katter's Australian Party was expected to hold three seats, with the Greens also on track to hold at least two and possibly three seats.

One Nation's Stephen Andrew and independent Sandy Bolton make up the final numbers.

The biggest victim of the night was former deputy premier Jackie Trad, who lost her seat of South Brisbane to the Greens' Amy MacMahon.

LNP deputy leader Tim Mander said the result was "incredibly disappointing", citing the inability for opposition parties to get any political oxygen amid the COVID-19 pandemic.

"It means the pandemic has had a major impact on another opposition as it has in other jurisdictions around the country and overseas," he told the ABC.

The pandemic was also a key factor in this year's ACT and Northern Territory election wins for Labor.

Queensland Deputy Premier Steven Miles said it was not so much about incumbency as the quality of the government's response to the pandemic and the failure of the opposition to show support.

"They criticised our health advice, they criticised the health officer, called for the borders to be opened when Queenslanders wanted the borders closed," he said.

"I don't think it's fair to say they just couldn't get oxygen ... what they did with the oxygen was wrong too."

Labor's primary vote of 39.5 per cent was based on a swing of 5.4 per cent.

The LNP secured 35.3 per cent of the primary vote, with half of the vote counted on Saturday night.

Significant traction was lost by One Nation, whose vote fell 6.7 per cent.

Labor senator Murray Watt told AAP he expected Labor would govern again in majority.

The swing was not consistent across the state, with Labor doing better in the southeast corner and the LNP performing better in regional areas.

Senior LNP MP David Crisafulli said there were effectively two elections under way.

"The mood in regional Queensland is palpable. They are waiting with baseball bats," he said.

Gold Coast based federal minister Karen Andrews put the swing in the southeast to Labor down to older voters who "probably feel safe with the borders closed" endorsing Ms Palaszczuk's strategy in dealing with the coronavirus.

"What we have been saying is that this is a crisis on two levels, health and economy, but clearly in some cases health was the most significant for people," she told the ABC.

Labor national president Wayne Swan said Ms Palaszczuk had earned an "enduring respect" for her approach to the pandemic.

Former LNP premier Campbell Newman said his party's stocks were already low before the pandemic.

"Spare me the COVID-19 excuse for what's happening tonight in Queensland," he tweeted.

"The LNP primary vote was 36 per cent a year ago -we had a problem prior to the pandemic."

Australian Associated Press