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Police pursuit comes to crashing end

Five men are in hospital after a two car crash following a hot pursuit by police in Northcote.

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A gun has been found in a BMW involved in a Northcote car crash that has left two people fighting for their lives and three others with serious injuries.

Police followed a black BMW after a laser detected the car speeding about 11.25am on Heidelberg Road.

A motorcyclist rode between the police car and the BMW and "continued to separate them," police say.

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Police gave chase after the BMW performed a U-turn then drove through a red light at the intersection of Jeffrey Street.

It is alleged that at the intersection of Heidelberg Road and Yarra Bend Road the BMW ran a second red light and collided with a silver vehicle.

One of the men from the BMW fled on the back of the motorcycle, which was last seen travelling west along Heidelberg Road.

He then jumped off the motorcycle and ran south into a park.

The four other male occupants of the BMW were injured and treated at the scene.

Two of the men have since been taken to The Alfred hospital and two have been taken to the Royal Melbourne Hospital.

The male driver and single occupant of the silver vehicle was seriously injured and taken to the Royal Melbourne Hospital.

The police vehicle was not involved in the crash.

During a search of the BMW a handgun was found in the car.

The Major Collision Investigation Unit will investigate the incident and Professional Standards Command will oversee the investigation.

The motorcycle involved was a red and black sports motorcycle, possibly a Honda.

Two men, including the motorcyclist and the man he whisked away from the black BMW remained on the loose.

Police helicopters were hovering over Yarra Bend Park as the manhunt continued on Monday afternoon.

Four of the other men in the car, all aged in their 20s and early 30s, are under police guard in hospital.

They are suffering fractures to their sternum, ankles and arms, and will face a range of criminal driving charges.

Investigators from the major collisions unit have spent hours scouring the tangled wreckage of the black BMW.

Assistant commissioner Andrew Crisp said the handgun taken from the car, and at least two rounds of ammunition found on the floor, showed there was "another element to this particular case".

He said it was too soon to know whether there was a link with Melbourne bikies clubs.

"I have attended a number of these types if incidents ... but we assume the motorcycle was trying to slow down the police vehicle," he said.

"It's the first time I've seen this kind of driving behaviour."

Assistant commissioner Crisp said there were a "number of complexities" in the circumstances surrounding the incident.

Police's professional standards command would probe the appropriateness of the car chase, he said.

Anyone with information about the incident is urged to contract Crime Stoppers on 1800 333 000 or visit www.crimestoppers.com.au.