A motorcyclist aged in his 20s has died after colliding with a car in Melbourne's south-east on Friday night.

His bike hit a car carrying two people at the corner of Heatherton and Clayton roads in Clayton South about 10.15pm.

A passing nurse tried to revive the rider but he died at the scene.

Victoria police spokeswoman Belle Nolan said officers were investigating whether the motorcyclist ran a red light.

‘‘The motorcycle was travelling west on Heatherton Road and the car was travelling north on Clayton Road,’’ she said.

Police will prepare a report for the Coroner.

The man’s death brings the state’s road toll to 86 compared with 84 for the same time last year.