Olivia Newton-John at a 2010 announcement about funding for the Olivia Newton-John Cancer and Wellness Centre.

Olivia Newton-John at a 2010 announcement about funding for the Olivia Newton-John Cancer and Wellness Centre. Photo: Penny Stephens

An unidentified man has reportedly killed himself at Olivia Newton-John's luxury Florida mansion.

Local newspaper the Palm Beach Post has quoted Florida policeman, Sergeant Scott Pascarella, saying the deceased is a male who is not related to Newton-John or her husband John Easterling, 61 and does not live at the home.

Sergeant Pascarella said Newton-John and Easterling are currently out of town and not staying at the sprawling beachfront Jupiter Inlet Colony home.

According to several US gossip websites, comedian Rosie O'Donnell - who sold her own Miami mansion for $US16.5 million ($18 million) in June - is under contract to buy the home for an estimated $US5.6 million.

Newton-John, who lost her sister Rona earlier this year to brain cancer, has yet to comment on the tragic circumstances unfolding at her home.

Jupiter Inlet Colony Police were called about 12.15pm to 104 Lighthouse Drive, Jupiter Inlet, and Sergeant Pascarella said although it was an apparent suicide police were treating it as a death investigation and would carry out full inquiries.

Jupiter Inlet Colony is a small coastal community in Palm Beach, with a population of just 360 and largely patronised by celebrities.

For help with emotional difficulties, contact Lifeline on 13 11 14 or www.lifeline.org.au. For help with depression, contact Beyond Blue on 1300 22 46 36 or at www.beyondblue.org.au.

-Jessica Wright