Police confirmed a 23-year-old man died when his motorbike collided with the BMW on Lady Denman Drive about 8.30am.

Police and emergency service personnel were called to the crash but officer in charge of traffic operations for ACT Policing Sergeant Stephen Booth said the motorcyclist died at the scene.

He said it was to early to say whether Friday's wet weather influenced the crash but a report will be prepared for the coroner.

"It's still early in the investigation. There are witnesses to the collision and we've been speaking to those. I believe another person coming along behind the car witnessed the collision," he said.

Both the BMW and the motorcycle were extensively damaged, with a lot of debris at the scene.

Paramedics took the driver and the passenger of the car to hospital but Sergeant Booth said their injuries were not believed to be serious.

"I imagine it would have been a horrific experience to be in a vehicle when this occurs. They'll be receiving all of the support services we have on offer," Sergeant Booth said.

One of the occupants of the car had already been discharged from hospital on Friday afternoon while the other was in a stable condition, an ACT Health spokeswoman said.

Lady Denman Drive remained closed in both directions for several hours and commuters were urged to avoid the area. The road has since reopened.

The death coincided with the release of the 2015 ACT Road Crash Report, which revealed about a third of the people who died or were injured on Canberra roads last year were cyclists, pedestrians and motorcyclists.

Five of the 15 people killed on ACT roads last year were vulnerable road users, the report also said.

Six people have died on ACT roads this year. At least two were motorcyclists.

Sergeant Booth warned Canberrans to take extra care on the roads given the inclement weather conditions.

"It's always disappointing to see people die on our roads, it's something we try really hard to educate drivers on, to get out there and say please take care, please don't drive while you're distracted or tired, please don't drink and use drugs while you drive," Sergeant Booth said.

"Unfortunately these keep occurring and we have to simply keep putting that message out there."

Anyone who witnessed the crash but has not yet spoken to police was urged to call Crime Stoppers on 1800 333 000.