A woman has lost part of her right arm in a single-vehicle crash on the Hume Highway near Yass.
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The woman, 62, was driving north on the highway when her car left the road just north of Yass Valley Way and crashed near a median strip about 10.30am.
A NSW Fire and Rescue spokesman said the woman had her right arm partially amputated as a result of the crash.
The spokesman said the car was towing a trailer at the time of the incident.
The woman was trapped in the car for several minutes, before fire and rescue crews removed the roof and a side of the car to free the woman.
She was airlifted to Canberra Hospital in a serious but stable condition.
One northbound lane remains closed near Yass Valley Way.
NSW Police have appealed for anyone who may have dash-cam footage of the crash to contact Yass police or CrimeStoppers on 1800 333 000.