Five people, including at least three from Canberra, are in hospital in stable conditions following a severe collision on the Hume Highway on Monday .
Two cars collided on the highway near Marulan about midday on Monday. The Hyundai sedan and Toyota Corolla were travelling southbound when they collided, before crashing into trees on the median strip.
The male driver of the Hyundai, a 24-year-old from Canberra, suffered serious leg injuries, while a male and female passenger inside the sedan sustained minor injuries.
A female passenger, a Canberra woman in her late 20s, in the Toyota suffered serious head injuries, and was taken to hospital by rescue helicopter.
A Goulburn Base Hospital spokeswoman said all four injured patients were now in a stable condition following the incident, but remained in hospital.
The driver of the Toyota, a 38-year-old Canberra man, was not injured in the crash but was taken to hospital under police guard for mandatory testing.
A NSW police spokesman said no charges have been laid in relation to the collision, with an investigation into the cause of the incident continuing.
Monday's collision led to long delays for drivers on the Hume Highway heading home from the long weekend.
One lane was closed in each direction while a clean-up of the collision site took place.