Luke Drever, 37, from Seaford Rise in South Australia and Kevin Reilly, 38, from Bill Hill in New South Wales, were arrested when officers attached to Strike Force Bluffview raided the remote property at Harolds Cross, about 12km north-east of Captains Flat, just after 8.30am on Saturday.

The raid occurred as bushfires were under control but still burning to the west of Braidwood in the nearby Tallaganda National Park.

Earlier, police said that suspecting firearms would be on the property, federal police Specialist Response Group tactical officers took the lead role on the raid in which a rifle, a shotgun, and $4500 in cash was seized from a shed used as a living quarters.

Strike Force Bluffview was formed in August last year to investigate the manufacture and supply of methylamphetamine (ice) in the NSW Southern Tablelands and includes detectives from the NSW police State Crime Command, South Australia police and the Australian Criminal Intelligence Commission.

Police found a large-scale clandestine laboratory spread across two sheds on the property and more than 500 items consistent with drug manufacture including eight stainless steel condensers, a 1000-litre stainless steel reaction vessel, glassware, precursors, gas burners, and several gas bottles.

Police described it as an "elaborate set-up" using "industrial-sized" equipment.

These included a ventilation system in one of the sheds, as well as a number of irrigation hoses hanging from the ceiling.

The seized items are now being examined by officers from the NSW chemical operations unit.

The men were charged with manufacturing a large commercial quantity of a prohibited drug.

Both men appeared at a special hearing of the Queanbeyan Local Court on Sunday, where they were formally refused bail via a video link, to re-appear again on Monday. They will appear again on March 3.