Kimberly-Clark, whose factory in the state's South East makes toilet paper, is responding to panic resulting from the spread of the deadly COVID-19.

According to a company spokesperson, their Kleenex toilet paper range for Australia and New Zealand, made at the SA mill, has led to production lines working 24/7.

The company says this is to deal with "increased demand" for their product that they see as "short-term".

While the company did not answer direct questions to reasons for the demand, they said: "We are also working closely with our customers to replenish supermarket shelves faster".

Dedicated supermarket shelves now go empty daily.

The demand for hand sanitisers and masks also remains at the top of shopping lists.

In many locations, including Asia where the disease first struck, toilet paper supplies began to quickly deplete from early last month.

Stockpiling of toilet paper became evident this week in Australia with the overflow of social media posts and television coverage.

In country SA, supermarkets feel the effects of the demand, including one supermarket located in the Mid North town of Clare.

Foodland staff told how they took delivery of their latest toilet paper stock on Wednesday and by Thursday afternoon the shelves were almost bare.

Staff members Tracey Giles and Jayne Lovell were shocked at customers' actions.

The women saw six to seven people line-up at once at the checkouts with toilet paper.

Worker Todd Hutchings shared how he had been told rice was also another sought-after item.

Meanwhile, supermarket giants such as Woolworths were also affected this week.

The customer demand has resulted in some Woolworths stores limiting toilet paper per customer.

The supermarket apologised to its customers for the shortage of supplies.