Barham's Royal Hotel owner Alan Forster fears the border closure will be harder on business than the first shutdown in April.

"We don't know the total outcome of what the actual closures are going to do, but in the pub here we feel it's probably going to be harder than the close down before," Mr Forster said.

"We're a small town, right on the border and 95 per cent of our trade comes from Victoria, but they will be locked in over there so we don't know what's going to happen this time, we think it's going to be harder.

"We've already had panic buying today.

"Within a few minutes of the the whole thing happening people just buying four or five slabs at a time."

Mr Forster owns the Royal Hotel in Barham in NSW, and just over the Murray River in Koondrook, Victoria, is The Mates Royal Hotel owned by Shane Membrey.

In the 30 years he's lived on the Murray River Mr Membrey says there's never been a border closure between the two states and he is not feeling confident about what it means for his business.

All his suppliers and many of his patrons come from across the border.

Separated only by 'one big old wooden bridge', the population of about 2000 people work, live and play between the two border towns.

"Koondrook hasn't got a great deal in it, it's just kind of like a one-horse town, where as Barham has two supermarkets, three petrol stations and so most of Koondrook goes to Barham. A lot of workers over this side work in Barham, so I don't know, there's going to be a lot of paperwork, I think," Mr Membrey said.

"Another little hiccup too, when I was over in the post office, there was a young girl who lives in NSW but hasn't changed her licence or registration yet, so she's still registered as Victorian. And there's a lot of that on the river actually."

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Over towards the cities of Albury and Wodonga, plumber Kade Bell-Chambers, owner of KBC Plumbing runs his business between the two states and said while there hasn't been a lot of information released yet about how the closure will impact daily jobs, he remained positive toward the adjustments he might need to make.

"There's not much we can do about it, we're in a situation that's never been seen before so I don't think there's a right or wrong way to do," Mr Bell-Chambers said.

"They've had to make their announcement and it's just something we've got to deal with and work out what we're going to do on the run.

"We won't cancel our work, we'll apply for the permits so our staff can cross the border. But if worse comes to worse and they say absolutely no crossing of the border, we'll set up on both sides.

"I've got a couple of plumbers who live in Wodonga and a couple who live here in Albury, so it just means we'll set up two bases either side of the border to keep working.

"At the end of the day you've just got to keep everyone safe and if you can keep people employed while being safe as well, it's a win-win."

Border-town hotel owner at Barham Hotel Carol Ramsey was also worried about the impact of the closures, but said people's safety comes first.

"We're living in these uncertain times and we've been dealing with it since March, so if we've got to deal with this for another few weeks, so be it, just so that we can get through it," Mrs Ramsey said.