Spain's Nadal had said in June that he had reservations about travelling to the Us amid the COVID-19 pandemic and he joins women's world No.1 Australian Ash Barty in skipping the tournament due to COVID-19 concerns.

"After many thoughts I have decided not to play this year's U.S. Open," Nadal said on Twitter.

"The situation is very complicated worldwide, the COVID-19 cases are increasing, it looks like we still don't have control of it.

"We know that the reduced tennis calendar is barbaric this year after 4 months stopped with no play, I understand and thank (everyone) for the efforts they are putting in to make it happen. We have just seen the announcement of Madrid not being played this year.

"This is a decision I never wanted to take but I have decided to follow my heart this time and for the time being I rather not travel."

The Madrid Open, which was scheduled to take place from September 12-20, was cancelled on Tuesday due to the rise of COVID-19 cases in the Spanish capital.

World No.1 Novak Djokovic, a three-time champion in New York, headlines the men's list along with last year's runner-up Daniil Medvedev and other top 10 players including Dominic Thiem, Stefanos Tsitsipas and Alexander Zverev.

Nine of the top 10 women's players, including 23-times grand slam champion Serena Williams and holder Bianca Andreescu, are on the entry list along with 2018 champion Naomi Osaka.

As many as 13 grand slam champions are in the women's draw including Romania's Simona Halep, the reigning Wimbledon champion and 2018 French Open winner and this year's Australian Open champion Sofia Kenin.

Organisers said the seedings would be announced closer to the start of the tournament which is scheduled for August 31.

Australian Associated Press