Wallabies coach Dave Rennie has made seven changes to his starting team for Saturday's clash, Australia's third with France in 11 days which comes after Tuesday's 28-26 loss to Les Bleus in Melbourne.

Livewire attacking halfback Tate McDermott will start for the first time for his country while hard-hitting backrower Lachie Swinton goes straight into the run-on team for his first Test of the year.

Some Wallabies fans will be disappointed to see prop Taniela Tupou relegated to a bench role after another powerhouse performance when promoted to start at AAMI Park, with Allan Alaalatoa returning to the starting role.

However, Tupou did much to turn the first Test in Australia's favour with his scrummaging and ball-running when introduced during the second half in Brisbane last week.

Swain will partner Lukhan Salakaia-Loto in the second row while Isi Naisarani will start at No.8 for the first time since the 2019 Rugby World Cup quarter-final, combining with skipper Michael Hooper and Swinton in a new-look backrow as Brumby Rob Valetini is benched.

McDermott partners sharp-shooting goalkicker Noah Lolesio in the halves, with Brumbies youngster Lolesio getting a third straight start as playmaker as veteran James O'Connor remains unavailable through injury.

Ikitau combines with Hunter Paisami in a hard-running midfield combination, with Paisami moving to inside centre as versatile veteran Matt To'omua drops to the bench.

Filipo Daugunu replaces an out-of-sorts Tom Wright on one wing with Tuesday night's Man of the Match Marika Koroibete on the opposite edge and Tom Banks retaining the fullback role after a promising performance.

Rebels hooker Jordan Uelese gets a recall as the bench hooker, with Angus Bell and Tupou the other front-row finishers.

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"We always knew with the scheduling of the series against a tough French side, that it would require a full squad effort and we're going to see that on Saturday night," said Rennie.

"We were disappointed with the result in Melbourne and we'll be out to rectify that with more accuracy and composure in key moments at Suncorp Stadium.

"As always, we've picked a team that has earned the right to wear the gold jersey and we're confident they'll get the job done in Brisbane."

The Wallabies won last week's first Test 23-21.

Wallabies: Tom Banks, Filipo Daugunu, Len Ikitau, Hunter Paisami, Marika Koroibete, Noah Lolesio, Tate McDermott, Isi Naisarani, Michael Hooper (c), Lachlan Swinton, Lukhan Salakaia-Loto, Darcy Swain, Allan Alaalatoa, Brandon Paenga-Amosa, James Slipper. Res: Jordan Uelese, Angus Bell, Taniela Tupou, Matt Philip, Rob Valetini, Jake Gordon, Matt To'omua, Reece Hodge.