China will send three astronauts to an unfinished space station, including the first female crew member to visit the station, where they are due to stay for six months.
It will be the second of four planned crewed missions to the station, which is due to be completed by the end of next year.
The Shenzhou-13 spacecraft will be launched at 12.23am Beijing time on Saturday, Lin Xiqiang, spokesman of the China Manned Space Program, told reporters.
Zhai Zhigang, 55, who hailed from China's first batch of astronaut trainees in the late 1990s, will be the mission commander for Shenzhou-13, Lin said.
Zhai will be accompanied by Wang Yaping, 41, and Ye Guangfu, 41.
Wang will be the first female astronaut to visit the Chinese station.
"We will definitely encounter physical and psychological problems, as well as problems related to the equipment and facility," Zhai told reporers on Thursday.
"Whether we can complete this flight mission well, depends on our team, our tenacious will and the fighting spirit of our three crew members."
The mission, known as Shenzhou-13, meaning "Divine Vessel" in Chinese, will be Zhai and Wang's second space mission and Ye's first.
China began construction of what will be its first permanent space station in April with the launch of Tianhe - the first and largest of the station's three modules.
Tianhe, slightly bigger than a city bus, will be the living quarters once the space station is completed.
The three-person crew on the previous Shenzhou-12 mission stayed in Tianhe for 90 days from June to September.
Australian Associated Press