The state posted 13,507 new COVID-19 cases on Wednesday, including 6533 from PCR tests and 6974 from rapid antigen tests.

It brings the total number of active cases in the state to 139,562.

COVID-19 Commander Jeroen Weimar said Wednesday's death toll was "one of the highest" he has seen.

It is the most deaths reported in the state since Victoria's second wave, when 59 fatalities were recorded on September 4, 2020.

"Our thoughts and condolences are with all families and friends of those 35 Victorians who we reported as having passed away with COVID in the last few days," he told reporters.

"It is again a sombre milestone that we should all reflect upon."

There are 1089 patients with COVID-19 in Victorian hospitals, of whom 113 are in intensive care and 40 on a ventilator.

Mr Weimar said 2712 health workers were on furlough due to being sick with the virus or looking after people with COVID-19.

He said more than 90,000 COVID-19 vaccine booster doses had been administered over the past week, after a blitz across state-run clinics.

About 58 per cent of Victorians aged over 70, 49 per cent aged over 60 and 34 per cent of over-18s have been tripled dosed.

Mr Weimar encouraged parents to "make it a priority" to get their children vaccinated before school returns next week.

Australian Associated Press