The new cases include 4504 from rapid antigen tests and 2422 from PCR lab tests, the health department said on Wednesday.

There are 42,016 active cases in the state, a decrease of more than 5000 from Tuesday.

Some 319 infected people are in hospital, 26 fewer than the previous day's figure, with 22 active cases in intensive care and eight on ventilators.

More than 56 per cent of Victorian adults have received three doses of a COVID-19 vaccine.

The latest figures come as the state is days from further restrictions easing, with indoor mask-wearing and working from home rules to be scrapped from 11.59pm on Friday.

Additionally, all remaining elective surgery restrictions will lift on Monday.

Primary school students in year 3 or above will continue to wear masks, as will teachers, but secondary students will not.

Masks will still be required on public transport, in taxis and rideshares, on planes, in airports and at hospitals and care facilities.

Hospitality, retail, court and corrective services workers will still have to don a mask.

Australian Associated Press