The UComms poll of 847 residents conducted on April 12 found independent candidate Monique Ryan held a 59 to 41 per cent two-party preferred lead over Mr Frydenberg in the inner-Melbourne electorate.

The poll also showed a 44 per cent disapproval rating for Mr Frydenberg's record as local MP and a 57.2 per cent disapproval rating of Prime Minister Scott Morrison.

Climate change and the environment was the number one concern of Kooyong voters, with 33.8 per cent indicating that it was their most important issue when deciding their vote.

"Mr Frydenberg and the Morrison government are missing out on the massive employment, investment and economic opportunities of transitioning to renewables," Dr Ryan said in a statement.

Dr Ryan's community campaign has so far mustered 1500 volunteers and more than 2000 donors providing nearly $1.2 million.

"There is a strong mood for change," she said.

The UComms poll had a 3.35 per cent margin of error.

Australian Associated Press