The truck was hauling two trailers when it crashed between Yass Valley Way and Wargeila Road on Wednesday at 9pm, NSW Ambulance said.

Hume Highway has been closed northbound with NSW police saying it would is likely be closed for the majority of Thursday.

One of the two southbound lanes is also closed.

All vehicles can divert around the closure via Yass Valley Way and the Barton Highway.

Police said the truck was carrying paint and thinners, which had been spread across about 100 metres on the road.

Firefighters put in place physical measures to prevent further spread of the liquid, before HAZMAT crews arrived on-scene and contained the mishap.

Fire and Rescue NSW said they were working with the Environment Protection Authority to deal with the spill at about midday.

Emergency services and a heavy vehicle tow truck were at the scene, as of 9.45am Thursday.

IN OTHER NEWS:

Hazmat crews were working to clean up the materials from the road, Hume Police District said about 11.45am.

A man was taken to hospital with a suspected broken arm.

Officers attached to the Hume Police District are investigating the circumstances surrounding the crash.

Anyone who witnessed the incident or has dashcam footage of the crash is urged to call Yass Police on 6226 9399.

More to come.

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