The in-form tennis player will instead return to Canberra at the conclusion of the final grand slam of the year.

Had he been available, Kyrgios could have turned Australia into a legitimate threat, however personal reasons dictated his decision to bypass the competition.

Kyrgios has spent the past three months playing in Europe and North America, where he has enjoyed an unprecedented run of form.

With his mother recovering from a medical procedure, the Canberra talent is determined to return home and reunite with his family.

As a result, Alex de Minaur will lead the Australian charge at the Davis Cup, in a team featuring Kyrgios' doubles partner Thanasi Kokkinakis.

Matt Ebden, Max Purcell, Alexei Popyrin and Jason Kubler make up the remainder of the squad that will travel to Germany for the competition's finals.

Australian captain Lleyton Hewitt was disappointed with Kyrgios' decision but remains confident he has a group capable of taking out the global tournament.

"It would have been great to have Nick in the team but unfortunately he was unavailable for this tie," Hewitt said.

"We fought through a really tough qualifying match back in March against Hungary which has now given us this opportunity to build on and the boys understand what's at stake.

"I look forward to Alex leading the team in Hamburg."

Kyrgios has surged into US Open contention in recent weeks with a stunning run.

The controversial figure has shown his trip to the Wimbledon final was no flash in the pan, building on that career-best performance throughout the North American hard-court swing.

Kyrgios had won nine-straight until last week's Canadian Open, a stretch that included tournament victories at the Atlanta Open and Washington Open. He also claimed the doubles title in Washington.

For so long an erratic performer, the 27-year-old has displayed an impressive mental calm and consistency throughout the past few months.

That has seen Kyrgios string multiple superb matches together and he has climbed to 28^th on the world rankings and into the seeds for the US Open, to start on August 29.

The Australian revealed the physical and mental toll of his success during the Canadian Open, and will this week put the finishing touches on his preparation for the grand slam tournament.

Kyrgios made an impressive start to his Cincinnati Masters campaign on Wednesday morning with a 7-5, 6-4 win over Alejandro Davidovich Fokina. He will now play 11th seed Taylor Fritz in the second round.

The 27-year-old is also playing doubles with Kokkinakis at the event, the pair opening their tournament with a win on Tuesday.

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