Emergency services were called to the Kings Highway crash about 2.20pm, where four people were reportedly trapped.

New South Wales Ambulance said the teenage boy had abdominal and chest injuries.

Also transported to Canberra Hospital was a 68-year-old woman with multiple limb fractures, a 29-year-old female with a fractured leg, an elderly male with back pain and a fifth person with a knee injury, the service said.

Road closures were still in place about 4pm, according to NSW Police.

The crash happened about 16 kilometres from Braidwood.