The 41-year-old was arrested during a raid on his Carindale home on Friday after a 25-year-old and a 23-year-old told police they'd been picked up from the Fortitude Valley nightclub precinct and assaulted on two separate nights in September.

The man, who cannot be named for legal reasons, appeared in the Brisbane Magistrates Court on Saturday charged with one count of deprivation of liberty and three counts of sexual assault.

Court documents allege he approached one of the women in an SUV on Wickham Street about 3.40am on September 8 and told her he was an Uber driver.

During the trip the woman opened the Uber app on her phone to realise the ride hadn't registered but believed he was a registered driver and arranged to pay him in cash.

They pulled up not far from her house where he exposed himself and sexually assaulted her, it's alleged.

According to prosecutors, he picked up the second woman and her friend about 4.50am on September 16, verbally confirming he had been booked by another friend who had already gone home.

After dropping the first woman home, he allegedly exposed himself, grabbing hold of the woman's arm and continuing to drive closer to her home when she tried to flee.

Both women told police they had been locked inside the vehicle and feared for their safety because he was much bigger than them, it's claimed.

CCTV footage allegedly backed up their statements to police.

"The defendant has committed these offences the past two weekends in a row ... (we) are concerned that he will continue driving around the Fortitude Valley and City areas in the early hours of the morning on weekends preying on vulnerable women," the documents state.

The man did not apply for bail and is due to appear in the Brisbane Magistrates Court on November 14.

Detectives are appealing for anyone with information on other incidents involving a black 2007 Land Rover Freelander to come forward.

- AAP