Left-arm spinner Matt Kuhnemann's claimed his maiden five-wicket haul before Marnus Labuschagne cashed in yet again with the bat to put Queensland in complete control of their Sheffield Shield clash with Tasmania.
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The Tigers collapsed to be all out for 182 early on day three in Townsville on Friday, having resumed on 4-150.
Queensland, having declared at 6-487 in their first innings, raced to 1-132 in their second innings before Bulls captain Usman Khawaja declared once again.
Labuschagne, who scored 136 in the first innings, finished unbeaten on 60, while Joe Burns (46no) also cashed in.
It left Tasmania with a daunting 438-run victory target, and means some of their batters could end up batting twice in the same day.
The Tigers moved to 0-36 in their second innings by tea on day three, with Caleb Jewell (22no) and Tim Ward (13no) making a steady start to the huge run chase.
Earlier, Tasmania were keen to dig in for the entire day after resuming their first innings at 4-150.
Top-scorer Jordan Silk added two runs to his overnight tally of 45 before falling victim to allrounder Jack Wildermuth.
Kuhnemann cleaned up the tail to finish with career-best figures of 5-60.
The 25-year-old, who made his first-class debut in February, has been given a chance to shine in the absence of World Cup squad member Mitchell Swepson.
The defending champions' attack has also been depleted by the absence of pacemen Michael Neser and Mark Steketee.
Silk's dismissal triggered a shocking collapse of 6-27, during which Kuhnemann conjured three wickets.
Paceman Gurinder Sandhu, playing his first Shield game for Queensland after stints with NSW and Tasmania, finished with figures of 3-44.
Australian Associated Press