Kyrgios has been one of few tennis stars to speak out in Djokovic's defence ahead of the Australian Open and said the 20-time grand slam champion had reached out via Instagram to thank him.

"I was not the one he was expecting to go out in the media and have his back," Kyrgios said on his No Boundaries podcast.

"As a human, he's obviously feeling quite alienated in all of this.

"As a human, that's a dangerous place to be in - when you feel like the world is against you, like you can't do anything right."

Kyrgios described Djokovic's situation as a "s***show" and teed off at Immigration Minister Alex Hawke over his handling of the Serbian superstar.

"Hawke said that he's a threat to our borders. Ah, no he's not. It's like he's a weapon of mass destruction at the moment," Kyrgios said.

"He's here to play tennis, he's not doing anything to anyone.

"The mistreatment of people in Melbourne has been atrocious in the last two years.

"I understand the anger towards him for not being vaccinated and getting a medical exemption, but if you look at it on face value, he's got his paperwork."

Kyrgios arrived in Melbourne on Sunday ahead of his first-round meeting with British qualifier Liam Broady and a possible encounter with world No.2 Daniil Medvedev in the second round.

The 26-year-old from Canberra - now ranked 114th in the world - spent the previous seven days in isolation after testing positive to COVID-19.

Kyrgios described having the virus as feeling like he was "smoking eight packs (of cigarettes) a day".

Australian Associated Press