While Assange's extradition must still be approved by the government, Monday's decision deals a serious blow to Assange's effort to fight his deportation from the United Kingdom in the courts.

US authorities want Australian-born Assange, 50, to face trial on 18 counts relating to WikiLeaks' release of vast troves of confidential US military records and diplomatic cables which they said had put lives in danger.

In December, the High Court in London overturned a lower court's ruling that he should not be extradited because his mental health problems meant he would be at risk of suicide, and on Monday the Supreme Court itself said it would not hear a challenge to that ruling.

"The application has been refused by the Supreme Court and the reason given is that application did not raise an arguable point of law," a spokesperson for the Supreme Court said.

The extradition decision will now need to be ratified by interior minister Priti Patel, after which Assange can try to challenge the decision by judicial review.

A judicial review involves a judge examining the legitimacy of a public body's decision.

An interior ministry spokesperson said it would not be appropriate to comment on the court's decision.

The High Court had accepted a package of assurances given by the United States, including that Assange would not be held in a so-called "ADX" maximum security prison in Colorado and that he could be transferred to Australia to serve his sentence if convicted.

Assange's lawyers said the decision to extradite Assange based on those pledges was "highly disturbing".

"We regret that the opportunity has not been taken to consider the troubling circumstances in which Requesting States can provide caveated guarantees after the conclusion of a full evidential hearing," Assange's lawyers said in a statement on Monday.

Australian Associated Press