Feyenoord and Roma will meet again in the playoffs to reach the Europa League's round of 16 in a repeat of last season's UEFA Conference League final.
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Roma won that match 1-0 in Tirana to give coach Jose Mourinho a sixth European trophy.
The draw at UEFA's headquarters in Switzerland on Monday pitted the teams who finished second in their Europa League groups with the clubs who were third in the Champions League groups.
AC Milan stayed alive in European competition by beating Newcastle United in their final Champions League group game and were rewarded with a two-legged match against Rennes.
Other highlights included Shakhtar Donetsk being drawn against Marseille and Benfica taking on Toulouse.
The playoff round begins with the first legs on February 15, with the return matches on February 22.
The eight winners will then take on the Europa League's group winners.
Draw in full:
Feyenoord v AS Roma
AC Milan v Stade Rennes
RC Lens v Freiburg
Young Boys v Sporting Lisbon
Benfica v Toulouse
Sporting Braga v Qarabag
Galatasaray v Sparta Prague
Shakhtar Donetsk v Olympique de Marseille
Australian Associated Press
