A two-storey house recently listed for sale was gutted by a fire overnight in the Moreton Bay suburb of North Lakes.
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The fire broke out in the early hours of Monday morning and fire crews and paramedics attended about 4.50am.
Three occupants of the home were assessed by Queensland Ambulance Service, with a teenage girl treated for smoke inhalation.
Two patients were taken to hospital for observation.
It took fire crews an hour to extinguish the flames, with two crews still on site about 8am monitoring hot spots.
A fire investigator was en route to investigate the cause of the blaze.