Four people were rushed to hospital after a white Hyundai Getz crashed into a concrete barricade in Parkes around 2am on Thursday.
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The car was travelling southbound on the Kings Avenue bridge before losing control and crashing near Bowen Place.
Three men and a woman had to be rescued from the car, with the roof having to be cut off to free the occupants.
All four were treated at the scene by paramedics.
One man was taken to hospital in a critical condition, while the remaining passengers were in a serious condition.
The road was closed for several hours while emergency crews were on the scene, but was re-opened to traffic in time for the morning commute.
Police are looking for any witnesses to the crash, or who may have dash-cam footage of the incident to contact Crime Stoppers on 1800 333 000.