Sharon Raczkowski's tattoo parlour was completely booked out for at least the next four months.
Tennis star Nick Kyrgios was even scheduled to get some new ink done this Sunday.
Despite a booming business, the Fyshwick-based Tattoo Xtreme will be closed from Thursday due to new restrictions imposed to stop the spread of coronavirus.
"There are no words," Ms Raczkowski said.
"I'm so devastated. I've got 10 staff in this business, all with families and mortgages and mouths to feed."
Even on the last day of business before the closure came into effect, the parlour was packed out with people getting some final ink, many having waited months for their appointments.
The closure of tattoo parlours under the federal government's restrictions also applies to beauty and nail salons.
Hairdressers and barbers will be exempt from the restrictions but strict social distancing rules will be in effect including a time limit of 30 minutes.
Ms Raczkowski said while she could understand measures had to be taken to stop the spread of COVID-19, some of the exemptions did not make sense.
"There's a double standard for hairdressers, because we can do a small walk-in tattoo in half an hour, or a piercing in that time," she said.
"We already had segregated bays and one client for one tattooist measures in place for the past two weeks.
"Its unfair that hairdressers are still trading with the same amount of physical contact that we do."
After many challenges over the years, Ms Raczkowski said the closure was the biggest crisis the parlour had faced in its 22 years in operation.
She said that staff at the parlour, all permanent, were devastated by the closure.
"I've had staff with me who started with me in their 20s and now they're in their 30s with houses and kids and mortgages," she said.
Ms Raczkowski said she feared with the closure of tattoo parlours, people would look to get underground tattoos if they couldn't get inked legally.
Despite the lockdown measures, the parlour owner said she was optimistic about the future.
"We're definitely going to reopen as soon as possible. There's been lots of ups and downs and but we keep coming back," she said.
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