The Davis Cup finals is too soon for his troublesome knee, but Nick Kyrgios still has his sights set on being fit for the Australian Open.
Kyrgios told Tennis Australia he was unavailable for the finals, which will be held in Italy from November 25-December 5, due to the injury.
Patellar tendinopathy in his left knee forced him to end his 2021 campaign in September, with the 26-year-old returning to Canberra for treatment.
Australia's team will instead be led by Alex de Minaur, with captain Lleyton Hewitt also naming John Millman, Jordan Thompson, Alexei Popyrin and John Peers in the team that will travel to Turin.
They'll face Croatia and Hungary in the group stages with a view to progressing to the quarter-finals.
The six group winners progress to the knockout stages, with the two best runners-up also going through.
"It's going to be really exciting to be back with the boys again at the Davis Cup finals," Hewitt said.
"Team selection is never easy. We will be led by our No.1 Alex de Minaur, who has had a really consistent three to four years on the tour and has established himself as a top player.
"Our main focus is on Turin and trying to get through our group stage to give ourselves the opportunity again to go through to the knockout quarter-finals.
"A big focus is on Croatia, our first match, followed by Hungary. They are both quality teams, they have done really well to qualify, especially Croatia, who've won the Davis Cup before.
"We need to prepare as if it's going to be a real battle against these countries. Croatia have the No.1 doubles team who won the recent Olympic Games.
"There's got to be as much focus on singles as well as doubles and trying to make out the best possible combinations."
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Kyrgios planned to undergo platelet-rich plasma therapy to help overcome his injury.
Canberra Raiders co-captain Jarrod Croker used the same treatment throughout the NRL season for his chronic knee condition, before opting to have stem-cell treatment to help alleviate the pain earlier this month.
PRP injections usually mean the athlete needs to rest for a couple of weeks before being able to return to training.
Kyrgios planned to be fit for the Australian Open in Melbourne from January 17.
The Australian Open faces being without its reigning champion Novak Djokovic due to the Victorian government's current mandate that all professional athletes need to be fully vaccinated against the coronavirus in order to train or play in the state.
Djokovic, who has a history of trading off-court barbs with Kyrgios, refuses to reveal his vaccination status, potentially ruling him out of defending his Australian Open crown and improving on his record 10 men's titles.